Translational Microbiome & Immune Tolerance Laboratory Research

Food Allergy & Immunotherapy

Why do some infants develop tolerance to peanut and milk while others mount IgE responses? We study the gut microbiome as a key architect of neonatal immune education, including how engineered probiotics can be deployed alongside oral immunotherapy to promote lasting tolerance.

Alpha-Gal Syndrome & Microbiome

Alpha-gal syndrome (AGS) is a rapidly emerging tick-borne red meat allergy with no current cure. We have identified specific gut microbiome functions that we hypothesize drive AGS development. We are actively recruiting students and postdocs to lead studies combining human cohort recruitment, multi-omic data generation, and in vitro and in vivo experiments to define the microbiome–immune interactions responsible for AGS.

Gut Microbiome Immune Sytem Interactions

The first months of life represent a critical window. We track how feeding practices — breastfeeding, formula, introduction of solids — shape the infant microbiome and its downstream effects on atopic disease risk, using longitudinal cohort studies with paired immunologic data.

Asthma & Microbiome

Asthma remains among the most prevalent chronic disease in children. We study how the gut microbiome — its community composition and functional output — shapes the immune pathways that drive distinct atopic respiratory phenotypes. Leveraging multiple cohorts, we integrate metagenomic, metabolomic, metatranscriptomic and clinical data to uncover the gut-lung axis mechanisms that determine who develops disease and why.

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